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The meta-analysis showed that the LIPG rs9958947 SNP was significantly associated with an increased risk of ischemic stroke in Asian populations (dominant (CC vs. We observed that the mean age of Malaysian stroke patients was less than that of stroke patients from Korea and China. A p value less than 0.05 was considered statistically significant.
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The meta-analysis was conducted using the software Comprehensive Meta-Analysis ver. Genotyping of LIPG rs9958947 SNP was performed for 241 Malaysians using real-time polymerase chain reaction, and the odds ratios (OR) with 95% confidence intervals were calculated. Therefore, this study investigates this association through a case–control study on a Malaysian population along with a comprehensive meta-analysis. Stroke is one of the top 5 leading causes of death in Malaysia, so it is of interest to investigate whether this SNP is associated with stroke risk in the Malaysian population.
This newly discovered SNP increases the risk of stroke in some Asian populations, including Chinese and Korean populations. The rs9958947 single nucleotide polymorphism (SNP) resides in the promoter region of the lipase G ( LIPG) gene.